July 17, 2018
The source for all pricing data was RED BOOK™ (Truven Health Analytics, Inc.) by using Wholesale Acquisition Cost (WAC), which is the manufacturer-reported price at which the manufacturer sells the drug to the wholesalers and direct purchasers, before any discounts or rebates.
Our study was limited to the brand name drugs.
Whenever possible, we used the information from the FDA labels to determine conditions that the drugs were approved to treat and the drug utilization. Other sources included clinical trials and practice guidelines. In case of drugs with multiple FDA-approved indications we selected the one that was common and where the typical drug utilization was well-defined.
As a rule, for each study drug, only the data for the drug’s National Drug Codes (NDCs) available for the entire study period (January 1, 2012- June 2017) were included. When several NDC codes were available for a drug during the study period, we selected a single code most likely to be used for the treatment presented based on its formulation, strength, and package size.
The annual cost for a typical patient was estimated twice, as of January 1, 2012 (except for Evzio – see above) and as of June 30, 2017. The typical cost per year (TC2012, TC2017) was calculated as WAC Unit Price x Utilization (with the utilization calculated according to the drug’s dose and schedule for the specific treatment based on the drug’s FDA label). Price change was calculated as Price Change= (TC2017/TC2012)*100. The number of price increases was counted as the number of WAC price changes for a specific NDC after January 1, 2012 and before July 1, 2017.